Structured-Light DLP Projector for Super-Resoluton Microscopy

Structured illumination microscopy (SIM) is among the most widely used super-resolution fluorescence microscopy techniques .

Up to now, the physical and chemical methods to achieve super-resolution imaging have reached the bottleneck, and the pursuit of higher microscope resolution is facing great challenges. This research is actually a generalized mathematical algorithm framework, which can double the imaging resolution of several commonly used fluorescence microscope instruments.

Take the turntable confocal microscope as an example. The normal resolution of its commercial instrument is about 160 nm. With this achievement, it can be improved to about 80 nm. Therefore, the team has pushed forward the bottleneck limit resolution that can be reached before from the perspective of optimization calculation.

Super-resolution three-dimensional (3D) optical microscopy has incomparable advantages over other high-resolution microscopic technologies, such as electron microscopy and atomic force microscopy, We present an approach of structured illumination microscopy (SIM) by using SICUBE SM7 and SM9 DMD projector for fringe projection and a low-coherence LED light for illumination. The article was published on Nature.

SM7 and SM9 DLP projectors adopt 385nm/405nm/485nm/615nm LED for light source.Besides ,Standard C-mount projectror lens can meet requirements of the microscope interface easily.

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